Generic

Pregabalin

Therapeutic Class

Central nervous system (CNS)

Pack Size

Prelica 25 mg Capsule: Each box contains 30 capsules (3 x 10's) in Alu-Alu blister pack.
Prelica 50 mg Capsule: Each box contains 30 capsules (3 x 10's) in Alu-Alu blister pack.
Prelica 75 mg Capsule: Each box contains 30 capsules (3 x 10's) in Alu-Alu blister pack.

Indications

Prelica® is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy and management of post herpetic neuralgia. It is also indicated for the adjunctive therapy for adult patients with partial onset seizures. It can be used for the management of fibromyalgia.

Therapeutic Class

Central nervous system (CNS)

Dosage & Administration

Neuropathic pain associated with diabetic peripheral neuropathy: The maximum recommended dose of Pregabalin (Prelica®) is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Post herpetic neuralgia: The recommended dose of Pregabalin (Prelica®) is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 75 mg two times a day, or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Adjunctive therapy for adult patients with partial onset seizures: Pregabalin (Prelica®) at doses of 150 to 600 mg/day has been shown to be effective as adjunctive therapy in the treatment of partial onset seizures in adults. The total daily dose should be divided and given either two or three times daily. In general, it is recommended that patients should be started on a total daily dose not greater than 150 mg/day (75 mg two times-a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day. Management of Fibromyalgia: The recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300-mg/day)-within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day).

Contraindications

Pregabalin is contraindicated in patients with known hypersensitivity to Pregabalin or any of its components.

Side Effects

The most common side effects include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and abnormal thinking.

Pregnancy & Lactation

Pregnancy: Pregnancy category C. So it should only use if potential benefit justifies the potential risks to the fetus. It is not known if pregabalin is excreted in human milk; it is, however, present in the milk of rats. So it should be used in nursing mother only if there is a clear benefit over the risk.

Precautions

Discontinuation of Pregabalin without tapering may produce insomnia, nausea, headache and diarrhea. So it should be tapered gradually over a minimum of 1 week rather than discontinued abruptly. Creatinine kinase may be elevated if treated with Pregabalin. It should be discontinued rapidly if myopathy is diagnosed or suspected or if creatinine kinase is elevated markedly.

Storage Conditions

Store in a cool & dry place, protect from light.