Generic

Azithromycin

Therapeutic Class

Antibacterial

Pack Size

Acos 500 mg tablet: Each box contains 6 tablets (2 x 3's) in Alu-Alu blister pack.
Acos dry powder for suspension: Each bottle contains dry powder for 30 ml suspension.

Indications

Azithromycin is an azalide, a sub-class macrolide antibiotics. Azithromycin demonstrates activity in vitro, against a wide range of Gram-positive and Gram-negative bacteria including : Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes (Group A) and other Streptococcal species; Haemophilusinfluenzae, parainfluenzae; Moraxellacatarrhalis; anaerobes pertussis; Bordetellaparapertussis; Neisseriagonorrhoeae and Chlamydia trachomatis. Azithromycin also demonstrates in vitro activity against Mycoplasmapneumoniae; Campylobacter spp., and Treponemapallidum.

Therapeutic Class

Antibacterial

Dosage & Administration

Adult : 500 mg once daily

Contraindications

Azithromycin is contraindicated is patients with a know hypersensitivity to Azithromycin or any of the macrolide antibiotics. Because of the theoretical possibility of ergotism, Azithromycin and Ergot derivatives should not be co-administered. As with erythromycin and other macrolides, rare serious allergic reactions, including angioneurotic edema and anaphylaxis, have resulted in recurrent symptoms and required a long period of observation and treatment.

Side Effects

Azithromycin is well tolerated with a low incidence of side-effects. The side-effects include nausea, vomiting, abdominal discomfort (pain/cramps). flatulence, diarrhoea, headache, dizziness, and skin rashes are reversible upon discontinuation of therapy. Reversible elevations in liver transaminases have been observed occasionally.

Pregnancy & Lactation

Pregnancy : US FDA pregnancy category B. In the animal studies, no evidence of harm to the fetus due to Azithromycin was found. Because animal reproduction studies are not always predictive of human response, Azithromycin should be use during pregnancy only if clearly needed. Lactation : It is not known whether Azithromycin is excreted in human milk. Caution should be exercised when Azithromycin is administered to nursing mother.

Precautions

As with any antibiotic, observation for sings of superinfection with non susceptible organism, including fungi is recommended.

Storage Conditions

Protect from light, store in dry place below 30°C. Store the reconstituted suspension at room temperature and use within 5 days. Discard any used medicine after 5 days. Keep out of reach out of children