Generic

Cefixime

Therapeutic Class

Antibacterial

Pack Size

Rofixim 200 mg capsule: Each box contains 10 capsules (2 X 5's) in Alu-Alu Blister Pack.
Rofixim 400 mg capsule: Each box contains 10 capsules (2 X 5's) in Alu-Alu Blister Pack.
Rofixim dry powder for Suspension: Each bottle contains dry powder for 50 ml (100 mg / 5 ml) suspension.
Rofixim dry powder for Suspension: Each bottle contains dry powder for 50 ml (200 mg / 5 ml) suspension.

Indications

Upper and lower respiratory tract infections, Urinary tract infections, Gonococcal urethritis, Acute otitis media, Skin & soft tissue infection.

Therapeutic Class

Antibacterial

Dosage & Administration

Rofixim® Capsule: 1 or 2 capsules (200 mg -400 mg) as a single dose or in 2 divided doses daily for 7-14 days, according to the severity of infection. Rofixim® Powder for Suspension: Child dose: 8 mg/kg daily as a single dose or in two divided doses for 7-14 days according to the severity of infection or for age; 1/2-1 years: 3.75 ml or 75 mg; 1-4 years: 5 ml or 100 mg; 5-10 years: 10 ml or 200 mg; 11-12 years: 15 ml or 300 mg; above 12 years: adult dose.

Contraindications

Patients with known hypersensitivity to cephalosporin group of drugs.

Side Effects

Cefixime is generally well tolerated. The majority of adverse reactions in clinical trials were mild and self-limiting in nature. Gastro-intestinal disturbances: diarrhea (if severe diarrhea occurs, Rofixim® should be discontinued), changes in the colour of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported; Central nervous system disturbances: headache, dizziness; Others: hypersensitivity reactions which usually subsided upon discontinuation of therapy; in frequents and reversible haemotological changes; elevation of serum amylase.

Precautions

Rofixim® should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance <20 ml. min-1).

Storage Conditions

Store in a cool & dry place, away from direct light.