PRODUCT DETAILS
Omeprazole BP

Zilon® (Omeprazole) a substituted benzimidazole, is an inhibitor of gastric acid secretion. Omeprazole inhibits secretion of gastric acid by blocking the hydrogen-potassium-adenosine triphosphatase enzyme system, the so-called \\\\\\\'proton pump\\\\\\\' of the gastric parietal cell. It is effective for the treatment of gastric and duodenal ulcers and particularly for erosive reflux oesophagitis. Orally administered Zilon® is absorbed rapidly but to a variable extent. Following absorption Zilon® is almost completely metabolized and rapidly eliminated mostly in the urine. Although the elimination half-life from plasma is short, being reported to be 0.5 to 1.5 hours, its duration of action with regard to inhibition of acid secretion is much longer and it is suggested that its distribution to the tissues particularly to the gastric parietal cells accounts for this action. Zilon® is highly bound (about 95%) to plasma proteins.

Presentation:

Zilon® 20 capsule : Each capsule contains omeprazole BP 20 mg in enteric coated Pellets.
Zilon® 40 capsule : Each capsule contains omeprazole BP 40 mg in enteric coated Pellets.

  Dosage and Administration

Benign gastric and duodenal ulcers including those complication therapy : 20 mg daily for 4 weeks in duodenal ulceration or 8 weeks in gastric ulceration, in severe cases the dose may be increased to 40 mg daily; long-term use is not recommended. Healing of reflux oesophagitis : 20 mg daily for 4 weeks, followed by a further 4-8 weeks if not fully healed; 40 mg daily has been given for 8 weeks in reflux oesophagitis refractory to other treatment; may be continued at 20 mg daily. Zollinger-Ellison syndrome : Initially 60 mg once daily; usual range 20-120 mg daily (above 80 mg in 2 divided doses). Larger doses of upto 180 mg daily in divided doses may be used or as prescribed by the physicians.

  Side Effects

Zilon® is well tolerated. Nausea, diarrhea, abdominal colic, paresthesia, dizziness and headache have been stated to be generally mild and transient and not requiring a reduction in dosage.

  Contraindications

There are no known contraindications to the use of Omeprazole.

  Use in Pregnancy and Lactation

Avoid in pregnancy unless there is no safer altenative. Breast feeding should be discontinued if the use of Omeprazole is considered essential.

  Drug Interaction

Omeprazole can delay the elimination of diazepam, phenytoin and warfarin. Reduction of warfarin or phenytoin dose may be necessary when omeprazole is added to treatment. There is no evidence of an interaction with theophyline, propranolol or antacids.

  Storage

Protect from light, store in dry place below 30∞ C.

  Commercial Pack

Zilon® 20 Capsule : Box contains 24 capsules (4 x 6\\\\\\\'s).
Zilon® 40 Capsule : Box contains 24 capsules (4 x 6\\\\\\\'s).

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