Rupatadine is indicated for the symptomatic treatment of Seasonal & Perennial Allergic Rhinitis and Urticaria.
Rupatadine is a long-acting, non-sedative antagonist of histamine H1-receptors. It also antagonizes the platelet-activating factor (PAF). Both histamine and PAF cause broncho constriction which leads to an increase in the vascular permeability and act as a mediator in the inflammatory process. With the dual mode of action, Rupatadine shows better therapeutic effect than an isolated antihistamine. Rupatadine possesses other anti-allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli and inhibition of the release of cytokines, particularly of the tumor necrosis factor alpha (TNF α) in human mastocytes and monocytes.
Adults and adolescents (above 12 years): The recommended dosage is 10 mg once daily, with or without food.
Sleepiness, headache, dizziness, dry mouth, fatigue, asthenia.
Hypersensitivity to Rupatadine or to any of the excipients.
No adequate data available. Caution should be exercised when prescribing Rupatadine to pregnant or lactating women; it is unknown whether Rupatadine is excreted into breast milk.
The concomitant administration of Rupatadine 20 mg and ketoconazole or erythromycin increases the systemic exposure, Rupatadine should be used with caution when it is administered concomitantly with these drug substances and other inhibitors of the isozyme CYP3A4. Rupatadine should be used with caution when it is co-administered with statins or CNS depressants or alcohol.
Store in cool & dry place, protected from light & moisture. Keep out of reach of children.
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