PRODUCT DETAILS
Cefuroxime USP

Cefuroxime is one of the bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. It is indicated for the treatment of infections caused by sensitive bacteria.


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Presentation:

Rofurox® 250 tablet : Each film coated tablet contains Cefuroxime Axetil USP equivalent to cefuroxime 250 mg.
Rofurox® 500 tablet : Each film coated tablet contains Cefuroxime Axetil USP equivalent to cefuroxime 500 mg.
Rofurox® dry powder for suspension: After reconstitution according to direction, each 5 ml suspension contains Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg.
Rofurox® 750 mg IM/IV injection: Each vial contains Cefuroxime Sodium USP equivalent to Cefuroxime 750 mg.

  Dosage and Administration

Usual dose: The usual adult dosage range is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750-mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5-gram dose every 8 hours is recommended. In bone and joint infections, a 1.5-gram dose every 8 hours is recommended. Surgical prophylaxis: A 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged. Pediatric Patients Above 3 Months of Age: Administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime.

  Side Effects

Generally Cefuroxime is well tolerated. However has been associated with nausea and vomiting in a small number of patients.

  Contraindications

Patients with known allergy to cephalosporins & pseudomembranous colitis are contraindicated.

  Use in Pregnancy and Lactation

while all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime has been safely used in later pregnancy to treat urinary and other infections.
Cefuroxime is excreted through the breast milk in small quantity. However, the possibility of sensitizing the infant should be kept in mind.

  Drug Interaction

Patients with known allergy to cephalosporins & pseudomembranous colitis are contraindicated.

  Over Dosage

Signs and symptoms: Overdosage of Cefuroxime can cause cerebral irritation leading to convulsions.
Management: Serum levels of Cefuroxime can be reduced by haemodialysis and peritoneal dialysis.

  Storage

Store in a cool and dry place away from direct light.
Keep out of reach of children
Storage condition for reconstituted Injection:
The reconstituted solutions are stable for 5 hours if stored at temperatures lower than 25°C and for 48 hours if stored at 4°C. Color intensification of reconstituted solution can be observed during storage.

  Commercial Pack

Rofurox® 250 tablet : Each box contains 1 Alu-Alu blister strips of 10 tablets.
Rofurox® 500 tablet : Each box contains 2 Alu-Alu blister strips of 4 tablets.
Rofurox® dry powder for suspension: Each bottle contains Cefuroxime Axetil powder to be reconstituted into 70 ml suspension.
Rofurox® 750 mg IM/IV injection: Each box contains one vial of 750 mg Cefuroxime and one ampoule of 10 ml sterile water for injection in blister pack.

  Others

In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750-mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5-gram dose every 8 hours is recommended.
In bone and joint infections, a 1.5-gram dose every 8 hours is recommended.
Surgical prophylaxis: A 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged.
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Pediatric Patients Above 3 Months of Age: Administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime.

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