PRODUCT DETAILS
Cefixime USP

Rofixim® (Cefixime) is a broad spectrum third generation oral cephalosporin antibiotic. It is bactericidal and stable to hydrolysis by many beta-lactamases. Rofixim® kills bacteria by interfering to the synthesis of bacterial cell wall. Rofixim® is highly active against Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis including beta-lactamase producers, most of the Enterobacteriaceae, beta haemolytic Streptococcus (group A & B) and Streptococcus pneumonia. Rofixim® is more active than other oral cepholosporins against Escherichia coli, klebsiella spp, Proteus mirabilis and Serratia marcescens. Rofixim® is also active against Streptococcus pyogenes & 40-50% of an oral dose is absorbed from gastrointestinal tract whether taken with meals or not. The plasma half life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% is bound to plasma protein. Rofixim® is mainly excreted unchanged through bile and urine.

Presentation:

Rofixim® 200 mg Capsule : Each capsule contains Cefixime Trihydrade USP equivalent to Cefixime 200 mg.
Rofixim® 400 mg Capsule : Each capsule contains Cefixime Trihydrade USP equivalent to Cefixime 400 mg.
Rofixim® Powder for Suspension : Each 5 ml reconstituted suspension contains Cefixime Trihydrade USP equivalent to Cefixime 100 mg.

  Dosage and Administration

Rofixim® Capsule: 1 or 2 capsules (200 mg -400 mg) as a single dose or in 2 divided doses daily for 7-14 days, according to the severity of infection. Rofixim® Powder for Suspension: Child dose: 8 mg/kg daily as a single dose or in two divided doses for 7-14 days according to the severity of infection or for age; 1/2-1 years: 3.75 ml or 75 mg; 1-4 years: 5 ml or 100 mg; 5-10 years: 10 ml or 200 mg; 11-12 years: 15 ml or 300 mg; above 12 years: adult dose.

  Side Effects

Cefixime is generally well tolerated. The majority of adverse reactions in clinical trials were mild and self-limiting in nature. Gastro-intestinal disturbances: diarrhea (if severe diarrhea occurs, Rofixim® should be discontinued), changes in the colour of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported; Central nervous system disturbances: headache, dizziness; Others: hypersensitivity reactions which usually subsided upon discontinuation of therapy; in frequents and reversible haemotological changes; elevation of serum amylase.

  Contraindications

Patients with known hypersensitivity to cephalosporin group of drugs.

  Storage

Store in a cool & dry place, away from direct light.

  Commercial Pack

Rofixim® 200 mg Capsule: Box containing 8 Capsules (2 X 4) in Alu-Alu Blister Pack.
Rofixim® 400 mg Capsule: Box containing 8 Capsules (2 X 4) in Alu-Alu Blister Pack.
Rofixim® Powder for Suspension (50 ml): Bottle containing dry powder for preparation of 50 ml suspension.

  Others

Rofixim® 50 ml Powder for suspension: First shake the bottle to loosen the powder. Then add 35 ml purified or boiled and cooled water with the help of our provided measuring cup into the bottle & shake to make 50 ml suspension.

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