Errin® (Erythromycin) is an effective macrolides that inhibits protein synthesis of bacteria, probably by blocking the amino-acyl translocation reaction of the 50S-ribosomal sub-unit. Errin® has a similar spectrum of activity of benzylpenicillin, of particular importance are betahemolytic Streptococci, Staphylococcus pyogenes, Neisseria, H. influenzae, some E. coli (but most Enterobacteria are resistant), Bordetella pertussis and Mycoplasma pneumoniae. It is bacteriostatic in low concentrations but can be bactericidal at high concentration. Errin® (Erythromycin) is widely distributed throughout body tissues and fluids with some retention in the liver and spleen. Protein binding of Erythromycin base is 73 percent and the half-life varies between 2-4 hours. Erythromycin is excreted in high concentrations through bile and upto 5% of an oral dose appears in the urine. Considerable amount may also be inactivated in the body. Food may interfere with the absorption of erythromycin, so it is best take at least half an hour before meals.
Powder for Suspension: Each 5 ml of reconstituted suspension contains Erythromycin Ethylsuccinate USP equivalent to 125 mg Erythromycin.
Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/ day, according to severity of infection.
|Infections||Dosage and Administration|
|Upper respiratory tract infection of mild to moderate severity||250 to 500 mg 4 times a day for 10 days|
|Lower respiratory tract infections of mild to moderate severity||250 to 500 mg 4 times a day for 10 days|
|Respiratory tract infection due to Mycoplasmapneumoniae||500 mg 6 hours for 5 to 10 days, treat severe infection for upto 3 weeks|
|Skin and soft tissue infection of mild to moderate severity||250 to 500 mg 4 times a day for 10 days|
|Pelvic inflammatory diseases (PID) acute due to Neisseriagonorrhoeae||500 mg 4 times a day for 10 to 14 days|
|Urogenital infection during pregnancy caused by Chlamydia trachomatis||500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days|
|Urethral, endocervical or rectal infections, uncomplicated||500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days|
|Non-gonococcalurethritis||500 mg 4 times daily for at least 7 days|
|Nesseriagonorrhoeae: Uncomplicated urethral, endocervical
or rectal infections and in penicillinase producing N. gonorrhoeae (PPNG)
|500 mg 4 times a day for 7 days|
|Early syphillis (primary, secondary) or latent syphilis of 1 year duration||500 mg 4 time a day 14 days|
|Severe or chronic diarrhoea||500 mg 4 times a day for 7 days|
|Rheumatic fever||250 mg 2 times daily|
|Bacterial endocarditis||1 g 2 hours prior to procedures, then 500 mg 6 hours after initial dose|
|Acne||500 mg twice daily for 3 months reduced to 250 mg twice daily for 3 months|
Erythromycin is contraindicated in patients hypersensitive to erythromycin.
Protect from light, store in cool & dry place.
Discard any unused portion of reconstituted Errin® suspension after 10 days
Powder for Suspension: Bottle containing dry powder to make 100 ml suspension.
Erythromycin is one of the safer antibiotics; gastro-intestinal disturbances and allergy being the commonest (0.5%-5%) adverse reactions.