PRODUCT DETAILS
Erythromycin Ethylsuccinate USP.

Errin® (Erythromycin) is an effective macrolides that inhibits protein synthesis of bacteria, probably by blocking the amino-acyl translocation reaction of the 50S-ribosomal sub-unit. Errin® has a similar spectrum of activity of benzylpenicillin, of particular importance are betahemolytic Streptococci, Staphylococcus pyogenes, Neisseria, H. influenzae, some E. coli (but most Enterobacteria are resistant), Bordetella pertussis and Mycoplasma pneumoniae. It is bacteriostatic in low concentrations but can be bactericidal at high concentration. Errin® (Erythromycin) is widely distributed throughout body tissues and fluids with some retention in the liver and spleen. Protein binding of Erythromycin base is 73 percent and the half-life varies between 2-4 hours. Erythromycin is excreted in high concentrations through bile and upto 5% of an oral dose appears in the urine. Considerable amount may also be inactivated in the body. Food may interfere with the absorption of erythromycin, so it is best take at least half an hour before meals.

Presentation:

Powder for Suspension: Each 5 ml of reconstituted suspension contains Erythromycin Ethylsuccinate USP equivalent to 125 mg Erythromycin.

  Dosage and Administration

Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/ day, according to severity of infection.

Infections Dosage and Administration
Upper respiratory tract infection of mild to moderate severity 250 to 500 mg 4 times a day for 10 days
Lower respiratory tract infections of mild to moderate severity 250 to 500 mg 4 times a day for 10 days
Respiratory tract infection due to Mycoplasmapneumoniae 500 mg 6 hours for 5 to 10 days, treat severe infection for upto 3 weeks
Skin and soft tissue infection of mild to moderate severity 250 to 500 mg 4 times a day for 10 days
Pelvic inflammatory diseases (PID) acute due to Neisseriagonorrhoeae 500 mg 4 times a day for 10 to 14 days
Urogenital infection during pregnancy caused by Chlamydia trachomatis 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days
Urethral, endocervical or rectal infections, uncomplicated 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days
Non-gonococcalurethritis 500 mg 4 times daily for at least 7 days
Nesseriagonorrhoeae: Uncomplicated urethral, endocervical
or rectal infections and in penicillinase producing N. gonorrhoeae (PPNG)
500 mg 4 times a day for 7 days
Early syphillis (primary, secondary) or latent syphilis of 1 year duration 500 mg 4 time a day 14 days
Severe or chronic diarrhoea 500 mg 4 times a day for 7 days
Rheumatic fever 250 mg 2 times daily
Bacterial endocarditis 1 g 2 hours prior to procedures, then 500 mg 6 hours after initial dose
Acne 500 mg twice daily for 3 months reduced to 250 mg twice daily for 3 months
Children : The usual oral dose is 30-50 mg/kg body weight per day in divided doses every 6 hours. For more severe infections, the dose may be doubled.

  Contraindications

Erythromycin is contraindicated in patients hypersensitive to erythromycin.

  Storage

Protect from light, store in cool & dry place.
Discard any unused portion of reconstituted Errin® suspension after 10 days

  Commercial Pack

Powder for Suspension: Bottle containing dry powder to make 100 ml suspension.

  Others

Adverse Reaction:
Erythromycin is one of the safer antibiotics; gastro-intestinal disturbances and allergy being the commonest (0.5%-5%) adverse reactions.

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